Research Fellow (Cancer Science Institute)
National University of Singapore
- Singapore
- Permanent
- Full-time
Accept ClosePress Tab to Move to Skip to Content LinkSearch JobsJob DescriptionJob Title: Research Fellow (Cancer Science Institute)Posting Start Date: 01/09/2025Job Description:Job DescriptionThe Research Fellow will play a key role in advancing the lab's research on RNA dynamics, RNA-protein interactions, and cellular responses to toxic RNA species. The incumbent will lead and support projects exploring RNA modifications, splicing, phase separation, and RNA-related disease mechanisms, utilizing advanced molecular and cellular biology techniques, high-throughput sequencing, and proteomics. The ultimate goal is to uncover therapeutic targets and novel strategies for combating RNA-related diseases.Key ResponsibilitiesResearch Execution
- Design, plan, and execute experiments to study RNA flux, RNA-protein interactions, RNA modifications, and splicing changes under stress and disease conditions.
- Investigate the molecular mechanisms of endogenous damaged RNA and exogenous viral RNA responses.
- Apply and further develop the lab's novel FANCI method to study RNA condensates and stress granules.
- Perform advanced assays such as iCLIP, RNA-seq, phase separation assays, and proteomic analysis (mass spectrometry).
- Contribute to the discovery and characterization of RNA condensates (e.g., DHX9 stress granules) and their roles in cytoprotection, immune signaling, and autophagy.
- Elucidate the roles of CSNK1E, PLCB2, and other regulators in antiviral immune responses using cell models, animal models, and patient-derived samples.
- Drive hypothesis-driven projects to uncover new RNA-related disease mechanisms and potential therapeutic targets.
- Collaborate with internal and external researchers on interdisciplinary projects.
- Mentor and supervise graduate students, research assistants, and interns in the lab.
- Prepare manuscripts for peer-reviewed journals and present findings at conferences and seminars.
- Contribute to grant writing and research proposals to secure funding.
- PhD in Molecular Biology, Biochemistry, Cell Biology, Biomedical Sciences, or related fields.
- Strong background in RNA biology, RNA-protein interactions, or cellular stress responses.
- Proficiency in molecular and cell biology techniques (RNA-seq, CRISPR/Cas9, immunofluorescence, RNA immunoprecipitation, etc.).
- Experience with RNA-centric technologies (e.g., iCLIP, RIP, phase separation assays) and/or proteomics (mass spectrometry) will be highly advantageous.
- Experience with animal models and handling patient-derived samples preferred but not mandatory.
- Proven publication track record in reputable journals.
- Strong analytical skills, critical thinking, and problem-solving abilities.
- Excellent communication skills and ability to work both independently and in a collaborative team environment.